The ubiquitin-proteasome system (UPS) regulates intracellular protein degradation, cellular homeostasis, and signal transduction. Therapeutics targeting ubiquitin enzymes—including E3 ligases, deubiquitinating enzymes (DUBs), and Proteolysis Targeting Chimeras (PROTACs)-represent a rapidly expanding frontier in targeted protein degradation for oncology, neurodegeneration, and autoimmune...
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